review

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

This is a very extensive review that provides many interesting perspectives on the difficult problem of reverse engineering of gene networks. In particular, it draws a lot of connections with disciplines outside of the life sciences.

Next-generation DNA sequencing

Next-generation DNA sequencing

This article is an interesting review of how Next-Generation sequencing differs from traditional Sanger sequencing, along with the pros and cons of each approach.  Overall, the advantage of NextGen sequencing seems to be that it bypasses some of the traditional...

Genetic design automation: engineering fantasy or scientific renewal?

Genetic design automation: engineering fantasy or scientific renewal?

The aim of synthetic biology is to make genetic systems more amenable to engineering, which has naturally led to the development of computer-aided design (CAD) tools. Experimentalists still primarily rely on project-specific ad hoc workflows instead of domain-specific tools, which...

What is Gene Synthesis?

What is Gene Synthesis?

This article explains what is gene synthesis, a combination of chemical and biological processes to produce synthetic DNA that does not exist in nature.  This technology transforming genetic engineering from a laborious art to an information-driven discipline. Although substantial advances have...

Gene Synthesis Demystified

The review on gene synthesis authored by Mike Czar is featured on the cover of Trends in Biotechnology. Read article.

Genetic design: rising above the sequence

Genetic design: rising above the sequence

Genetic engineering has developed around technologies enabling the targeted in vitro recombination of DNA molecules found in living organisms. As a result, the development of new DNA molecules has been primarily focused on cloning strategies that allow their assembly from...