parameter estimation

Noise in synthetic genetic oscillators

Noise in synthetic genetic oscillators

This paper focuses on characterizing the stochastic dynamics of previously described synthetic genetic oscillators. It is a very nice combination of experimental and computational work. The computational aspect includes both image analysis and parameter estimation. They breakdown the noise into different...

Parameter estimation at the whole cell level

Parameter estimation at the whole cell level

This paper raises a number of interesting issues relative to the estimation of parameters of whole-cell models. The challenge here is obviously the underdetermination of the problem when the number of parameters is very large. This challenge calls both for...

Parameterization of a Stochastic Model of Gene Expression from Adaptive Imaging Cytometry Data

Parameterization of a Stochastic Model of Gene Expression from Adaptive Imaging Cytometry Data

Supplementary material to a manuscript under review. The manuscript can be downloaded from the link below. 

Abstract

Recent decades have yielded an understanding of cellular behavior as arising from a complicated soup of noisy molecular interactions. Systems biologists [...]

407
Views
545
DLs

Parameter estimation preprint

We just submitted a revised version of a manuscript describing the analysis of data collected using our GenoSIGHT software. The paper shows that this data can be used to estimate parameters of gene network models. This manuscript is under consideration...

Adaptive imaging cytometry to estimate parameters of gene networks models in systems and synthetic biology

Adaptive imaging cytometry to estimate parameters of gene networks models in systems and synthetic biology

Supplementary material to a manuscript under review. The manuscript can be downloaded from the link below. 

Abstract

Recent decades have yielded an understanding of cellular behavior as arising from a complicated soup of noisy molecular interactions. Systems biologists [...]

407
Views
545
DLs