gene synthesis

Cloning forever

No design needed! Over the last six months, I spent considerable time and efforts trying to engage biologists in discussions about the design of expression vectors. My goal has been to better understand the design rules applicable in different domains...

Announcing gene synthesis course March 8-13 2015

We are pleased to announce that we will be offering our gene synthesis course again in the spring 2015. Gene synthesis technologies are rapidly changing research paradigms in molecular biology. The purpose of this course is to provide students a...

Interview with Andrew Snyder-Beattie about security in synthetic biology.

I was recently interviewed by Andrew Snyder-Beattie from the Future of Humanity Institute. I am putting edited excerpts from this interview below with the hope of engaging a discussion.  During this discussion, I am advocating that we work toward the development...

DNAFactory: A Gene Synthesis Game

We present our very first video game!  Targeted toward middle- and high-school students, DNAFactory demonstrates the steps a Gene Synthesis factory or laboratory would go through to produce DNA molecules; specifically, when creating a DNA sample, the target sequence is...

synthetic biology security

Developing a culture of security for synthetic biology

I was recently interviewed by Andrew Snyder-Beattie from the Future of Humanity Institute. I am putting edited excerpts from this interview below with the hope of engaging a discussion.   Andrew: What  should be done to address the risks of synthetic...

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

During the 2009 H1N1 influenza pandemic, vaccines for the virus became available in large quantities only after human infections peaked. To accelerate vaccine availability for future pandemics, we developed a synthetic approach that very rapidly generated vaccine viruses from sequence...

Creation of a bacterial cell controlled by a chemically synthesized genome

Creation of a bacterial cell controlled by a chemically synthesized genome

We report the design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only...

Improving DNA Manufacturing Through Standardization

Improving DNA Manufacturing Through Standardization

 

By framing gene synthesis as a manufacturing problem, it is possible to utilize common Industrial Engineering (IE) principles that have been applied to numerous macroscale systems in the burgeoning realm of DNA fabrication. These techniques have been successfully employed in an academic [...]

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This manuscript was submitted for presentation at IWBDA 2013. It was not accepted. The reviews we received are copied below. The manuscript will eventually be revised and published elsewhere. ----------------------- REVIEW 1 --------------------- PAPER: 11 TITLE: Improving DNA Manufacturing Through...

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