experimental

Feedback Limits Cell Division Variability

Feedback Limits Cell Division Variability

Entrainment of a genetic oscillator

Entrainment of a genetic oscillator

This paper from Bill Mather group in the Physics Department at Virginia Tech shows how a genetic oscillator responds to noisy signals. The authors show that the oscillator gets entrained despite the noise affecting the input signal. This is a...

Testing of a New Integrated Model of the Yeast START Transition

Testing of a New Integrated Model of the Yeast START Transition

We propose a new model of the yeast start transition. We tested the accuracy of the model by simulating various mutants not described in the literature. The cell cycle is composed of bistable molecular switches that govern the transitions between...

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

During the 2009 H1N1 influenza pandemic, vaccines for the virus became available in large quantities only after human infections peaked. To accelerate vaccine availability for future pandemics, we developed a synthetic approach that very rapidly generated vaccine viruses from sequence...

A Whole-Cell Computational Model Predicts Phenotype from Genotype

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. We report a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes...

Measurement and modeling of transcriptional noise in the cell cycle regulatory network

Measurement and modeling of transcriptional noise in the cell cycle regulatory network

Fifty years of genetic and molecular experiments have revealed a wealth of molecular interactions involved in the control of cell division. In light of the complexity of this control system, mathematical modeling has proved useful in analyzing biochemical hypotheses that...

Single-molecule analysis of gene expression using two-color RNA labeling in live yeast

Single-molecule analysis of gene expression using two-color RNA labeling in live yeast

This looks like a great method to investigate the dynamics of molecular noise. Curious to compare it with FISH data.

Measurements modeling transcription noise makes the cover of Cell Cycle

The October issue of Cell Cycle includes an article reporting our efforts to measure and model the transcriptional noise affecting the the regulatory network controlling the cell cycle in the baker yeast (Saccharomyces cerevisiae). The journal cover page features an...

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