cell cycle

Feedback Limits Cell Division Variability

Feedback Limits Cell Division Variability

Modeling a Minimal CDK Network

Modeling a Minimal CDK Network

This paper reports a computational analysis of the minimal CDK network engineered in fission yeast (doi:10.1038/nature09543). It had been observed that a Cdk-inhibitory mechanism working through tyrosine phosphorylation of the kinase subunit, which is essential for modern fission yeast, is dispensable...

Minimal Cell Cycle

Minimal Cell Cycle

This is a great example of a paper where synthetic biology meets systems biology. The authors developed a minimal cell cycle regulatory network by engineering a synthetic CDK. To simplify the cell cycle control machinery, a cassette expressing a fusion of cdc13 and cdc2under...

leave it to chance cover

Leave it to chance or not

Carolyn Beans wrote a blog post about our project to develop stochastic models of the regulatory network controlling cell division.  She was particularly interested in aspects of cell physiology that are affected by random events and how cells manage to...

Testing of a New Integrated Model of the Yeast START Transition

Testing of a New Integrated Model of the Yeast START Transition

We propose a new model of the yeast start transition. We tested the accuracy of the model by simulating various mutants not described in the literature. The cell cycle is composed of bistable molecular switches that govern the transitions between...

Stochastic modeling of the cell cycle goes on…

A couple of weeks ago, we received the renewal of the NIH grant funding our collaboration with John Tyson to develop stochastic models of the regulatory network controlling the cell cycle in yeast. This is the third funding cycle of...

funding nih nsf

NIH proposal gets amazing score

The proposal to renew the funding supporting our collaboration with John Tyson was examined by the NIH study section last week. We got a score of 18, which places in the top 2%. At NIH a good score is a...

Measurement of transcriptional noise in the cell cycle regulatory network

Measurement of transcriptional noise in the cell cycle regulatory network

These are the raw images collected to analyze the noise affecting transcription in the control of the cell cycle in yeast. 

388
Views
928
DLs

This data set is almost complete. We are still working on uploading the NET1 and SIC1 data.

1 2