systems biology

Synthetic Biology Summer Schools

For graduate students interested in getting intensive training in synthetic biology, there are several summer schools worth considering: CSHL Summer School in Synthetic Biology: This program spans 2 weeks and combines lectures and intensive lab experience. Application deadline is April...

Feedback Limits Cell Division Variability

Feedback Limits Cell Division Variability

Apply to Q-Bio Summer School

There is still time to apply to the 2016 Q-Bio Summer School. Applications are due on Monday, February 16 at 11:59pm (MST). The application requires a CV and a 1-page statement of interest in the summer school (combined into a...

Minimal Cell Cycle

Minimal Cell Cycle

This is a great example of a paper where synthetic biology meets systems biology. The authors developed a minimal cell cycle regulatory network by engineering a synthetic CDK. To simplify the cell cycle control machinery, a cassette expressing a fusion of cdc13 and cdc2under...

Testing of a New Integrated Model of the Yeast START Transition

Testing of a New Integrated Model of the Yeast START Transition

We propose a new model of the yeast start transition. We tested the accuracy of the model by simulating various mutants not described in the literature. The cell cycle is composed of bistable molecular switches that govern the transitions between...

Parameter estimation at the whole cell level

Parameter estimation at the whole cell level

This paper raises a number of interesting issues relative to the estimation of parameters of whole-cell models. The challenge here is obviously the underdetermination of the problem when the number of parameters is very large. This challenge calls both for...

Parameterization of a Stochastic Model of Gene Expression from Adaptive Imaging Cytometry Data

Parameterization of a Stochastic Model of Gene Expression from Adaptive Imaging Cytometry Data

Supplementary material to a manuscript under review. The manuscript can be downloaded from the link below. 

Abstract

Recent decades have yielded an understanding of cellular behavior as arising from a complicated soup of noisy molecular interactions. Systems biologists [...]

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Adaptive Imaging Cytometry

Adaptive Imaging Cytometry

The use of microfluidics in live cell imaging allows the acquisition of dense time-series from individual cells that can be perturbed through computer-controlled changes of growth medium. Systems and synthetic biologists frequently perform gene expression studies that require changes in...

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