noise

Noise in synthetic genetic oscillators

Noise in synthetic genetic oscillators

This paper focuses on characterizing the stochastic dynamics of previously described synthetic genetic oscillators. It is a very nice combination of experimental and computational work. The computational aspect includes both image analysis and parameter estimation. They breakdown the noise into different...

Entrainment of a genetic oscillator

Entrainment of a genetic oscillator

This paper from Bill Mather group in the Physics Department at Virginia Tech shows how a genetic oscillator responds to noisy signals. The authors show that the oscillator gets entrained despite the noise affecting the input signal. This is a...

leave it to chance cover

Leave it to chance or not

Carolyn Beans wrote a blog post about our project to develop stochastic models of the regulatory network controlling cell division.  She was particularly interested in aspects of cell physiology that are affected by random events and how cells manage to...

Measurement and modeling of transcriptional noise in the cell cycle regulatory network

Measurement and modeling of transcriptional noise in the cell cycle regulatory network

Fifty years of genetic and molecular experiments have revealed a wealth of molecular interactions involved in the control of cell division. In light of the complexity of this control system, mathematical modeling has proved useful in analyzing biochemical hypotheses that...

Measurements modeling transcription noise makes the cover of Cell Cycle

The October issue of Cell Cycle includes an article reporting our efforts to measure and model the transcriptional noise affecting the the regulatory network controlling the cell cycle in the baker yeast (Saccharomyces cerevisiae). The journal cover page features an...

Controlling Gene Expression Noise by Preventing Interchromosomal Interactions

Controlling Gene Expression Noise by Preventing Interchromosomal Interactions

In this paper, the authors examine intrinsic and extrinsic noise in the yeast pheromone response MAP kinase pathway. The transcription factor Ste12 is regulated by this kinase pathway, and there are two partially redundant repressors, Dig1 and Dig2, that interact...

Stochastic gene expression in a single cell

Stochastic gene expression in a single cell

Seminal paper that measures the intrinsic and extrinsic noise in different strains of E.coli. This was the first paper to experimentally demonstrate the presence of molecular noise in gene expression.

Method of Gene Regulation Influences Intrinsic Noise Independently of Expression Levels

Method of Gene Regulation Influences Intrinsic Noise Independently of Expression Levels

Cell-to-cell variability in gene expression (a.k.a. gene expression noise) in a genetically identical population of cells is the result of a combination of extrinsic and intrinsic “noise”. Extrinsic noise is the result of variations in the cellular environment (e.g. cells...

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