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Noise in synthetic genetic oscillators

Noise in synthetic genetic oscillators

This paper focuses on characterizing the stochastic dynamics of previously described synthetic genetic oscillators. It is a very nice combination of experimental and computational work. The computational aspect includes both image analysis and parameter estimation. They breakdown the noise into different...

CRISPR-Cas9:Rational design of highly active sgRNAs

A group led by David Root from the Broad Institute published a nice paper published in Nature Biotechnology (10.1038/nbt.3026) describing a predictive model of the sgRNA target sequence cleavage efficiency.  They created a pool of sgRNAs, tiling across all possible target...