gene expression

Noisy foresight

Twenty years ago, I was just a boy with a crazy dream of building stochastic models of the noise affecting the expression of genes in living cells. Back in the 90s this idea sounded like an heresy. The dominant paradigm...

Universal genetic parts for bacteria

Universal genetic parts for bacteria

This paper describes UBER, a set of universal genetic parts for bacteria.  This gene expression system for bacteria relying on a self-regulated T7 promoter. The advantage of this system is that it can be ported across species. The system is...

Experimental design to optimize multigene expression systems

Experimental design to optimize multigene expression systems

This is a very dense paper that describes an principled approach to design experiments minimizing the number of constructs to test to optimize the expression of expression systems that rely on the co-expression of multiple genes. My understanding is that...