systems biology

Feedback Limits Cell Division Variability

Feedback Limits Cell Division Variability

Entrainment of a genetic oscillator

Entrainment of a genetic oscillator

This paper from Bill Mather group in the Physics Department at Virginia Tech shows how a genetic oscillator responds to noisy signals. The authors show that the oscillator gets entrained despite the noise affecting the input signal. This is a...

Testing of a New Integrated Model of the Yeast START Transition

Testing of a New Integrated Model of the Yeast START Transition

We propose a new model of the yeast start transition. We tested the accuracy of the model by simulating various mutants not described in the literature. The cell cycle is composed of bistable molecular switches that govern the transitions between...

Parameter estimation at the whole cell level

Parameter estimation at the whole cell level

This paper raises a number of interesting issues relative to the estimation of parameters of whole-cell models. The challenge here is obviously the underdetermination of the problem when the number of parameters is very large. This challenge calls both for...

Adaptive Imaging Cytometry

Adaptive Imaging Cytometry

The use of microfluidics in live cell imaging allows the acquisition of dense time-series from individual cells that can be perturbed through computer-controlled changes of growth medium. Systems and synthetic biologists frequently perform gene expression studies that require changes in...

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

This is a very extensive review that provides many interesting perspectives on the difficult problem of reverse engineering of gene networks. In particular, it draws a lot of connections with disciplines outside of the life sciences.

A Whole-Cell Computational Model Predicts Phenotype from Genotype

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. We report a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes...