synthetic biology

Decoupling assembly and submission standards

Decoupling assembly and submission standards

Rule-based design of synthetic transcription factors

Rule-based design of synthetic transcription factors

To design and build living systems, synthetic biologists have at their disposal an increasingly large library of naturally derived and synthetic parts. These parts must be combined together in particular orders, orientations, and spacings to achieve desired functionalities. These structural...

The Synthetic Biology Open Language – SBOL

The Synthetic Biology Open Language – SBOL

The re-use of previously validated designs is critical to the evolution of synthetic biology from a research discipline to an engineering practice. Here we describe the Synthetic Biology Open Language (SBOL), a proposed data standard for exchanging designs within the...

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

During the 2009 H1N1 influenza pandemic, vaccines for the virus became available in large quantities only after human infections peaked. To accelerate vaccine availability for future pandemics, we developed a synthetic approach that very rapidly generated vaccine viruses from sequence...

Creation of a bacterial cell controlled by a chemically synthesized genome

Creation of a bacterial cell controlled by a chemically synthesized genome

We report the design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only...

Design of expression vectors for Chlamydomonas reinhardtii using domain-specific language

Design of expression vectors for Chlamydomonas reinhardtii using domain-specific language

The design of expression vectors often requires to follow specific rules dictated by the requirements of a project. In this paper, we introduced the GenoCAD grammar editor. We demonstrated how it could be used to capture set of design rules...

We need theoretical physics approaches to study living systems

We need theoretical physics approaches to study living systems

This isn’t a research paper, but this editorial makes a very good point about biological modelling; one that runs counter to the mindset of many biologists (including me). Their main point is that it is not necessary (or even preferable)...

Next-generation DNA sequencing

Next-generation DNA sequencing

This article is an interesting review of how Next-Generation sequencing differs from traditional Sanger sequencing, along with the pros and cons of each approach.  Overall, the advantage of NextGen sequencing seems to be that it bypasses some of the traditional...

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