synthetic biology

Noise in synthetic genetic oscillators

Noise in synthetic genetic oscillators

This paper focuses on characterizing the stochastic dynamics of previously described synthetic genetic oscillators. It is a very nice combination of experimental and computational work. The computational aspect includes both image analysis and parameter estimation. They breakdown the noise into different...

Entrainment of a genetic oscillator

Entrainment of a genetic oscillator

This paper from Bill Mather group in the Physics Department at Virginia Tech shows how a genetic oscillator responds to noisy signals. The authors show that the oscillator gets entrained despite the noise affecting the input signal. This is a...

Bacterial tape recorder

Bacterial tape recorder

This paper describes a bacterial tape recorder. E.coli engineered to be a bacterial tape recorder by allowing it change its genome in response to chemical signals. This is one of these mind-blowing papers that the Lu’s lab is known for. It’s...

Universal genetic parts for bacteria

Universal genetic parts for bacteria

This paper describes UBER, a set of universal genetic parts for bacteria.  This gene expression system for bacteria relying on a self-regulated T7 promoter. The advantage of this system is that it can be ported across species. The system is...

Experimental design to optimize multigene expression systems

Experimental design to optimize multigene expression systems

This is a very dense paper that describes an principled approach to design experiments minimizing the number of constructs to test to optimize the expression of expression systems that rely on the co-expression of multiple genes. My understanding is that...

Plant Synthetic Biology

Plant Synthetic Biology

Plant synthetic biology requires software tools to assist on the design of complex multi-genic expression plasmids. Here a vector design strategy to express genes in plants is formalized and implemented as a grammar in GenoCAD, a Computer-Aided Design software that...

CRISPR Cas9 Synthetic Eukaryotic Transcription Factors

CRISPR Cas9 Synthetic Eukaryotic Transcription Factors

The CRISPR Cas9 technology is used to design synthetic transcription factors in eukaryotes. The approach is used to design activators and repressors. Data shows that this approach can work in yeast and mammalian cells. This paper comes from Tim Lu’s group at...

Opiate synthesis in yeast

Opiate synthesis in yeast

This article got a lot of attention because of its potential biosecurity implications. Even though the paper only describes the synthesis of an intermediate, media quickly extrapolated to envision this as an avenue to home-brewed morphine and other addictive drugs....

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