peccoud lab

Feedback Limits Cell Division Variability

Feedback Limits Cell Division Variability

Testing of a New Integrated Model of the Yeast START Transition

Testing of a New Integrated Model of the Yeast START Transition

We propose a new model of the yeast start transition. We tested the accuracy of the model by simulating various mutants not described in the literature. The cell cycle is composed of bistable molecular switches that govern the transitions between...

Plant Synthetic Biology

Plant Synthetic Biology

Plant synthetic biology requires software tools to assist on the design of complex multi-genic expression plasmids. Here a vector design strategy to express genes in plants is formalized and implemented as a grammar in GenoCAD, a Computer-Aided Design software that...

Database of standard biological parts derived from plasmid features

Database of standard biological parts derived from plasmid features

Synthetic biologists rely on databases of standard biological parts to design genetic devices and systems. The Registry of Standard Biological Parts and other community resources provide the sequences and descriptions of thousands of genetic parts. The content of these database  is often...

Rule-based design of synthetic transcription factors

Rule-based design of synthetic transcription factors

To design and build living systems, synthetic biologists have at their disposal an increasingly large library of naturally derived and synthetic parts. These parts must be combined together in particular orders, orientations, and spacings to achieve desired functionalities. These structural...

Adaptive Imaging Cytometry

Adaptive Imaging Cytometry

The use of microfluidics in live cell imaging allows the acquisition of dense time-series from individual cells that can be perturbed through computer-controlled changes of growth medium. Systems and synthetic biologists frequently perform gene expression studies that require changes in...

The Synthetic Biology Open Language – SBOL

The Synthetic Biology Open Language – SBOL

The re-use of previously validated designs is critical to the evolution of synthetic biology from a research discipline to an engineering practice. Here we describe the Synthetic Biology Open Language (SBOL), a proposed data standard for exchanging designs within the...

If You Can’t Measure It, You Can’t Manage It

If You Can’t Measure It, You Can’t Manage It

This article is part of the About My Lab Collection.

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