noise

Feedback Limits Cell Division Variability

Feedback Limits Cell Division Variability

Entrainment of a genetic oscillator

Entrainment of a genetic oscillator

This paper from Bill Mather group in the Physics Department at Virginia Tech shows how a genetic oscillator responds to noisy signals. The authors show that the oscillator gets entrained despite the noise affecting the input signal. This is a...

Measurement and modeling of transcriptional noise in the cell cycle regulatory network

Measurement and modeling of transcriptional noise in the cell cycle regulatory network

Fifty years of genetic and molecular experiments have revealed a wealth of molecular interactions involved in the control of cell division. In light of the complexity of this control system, mathematical modeling has proved useful in analyzing biochemical hypotheses that...

Single-molecule analysis of gene expression using two-color RNA labeling in live yeast

Single-molecule analysis of gene expression using two-color RNA labeling in live yeast

This looks like a great method to investigate the dynamics of molecular noise. Curious to compare it with FISH data.

Controlling Gene Expression Noise by Preventing Interchromosomal Interactions

Controlling Gene Expression Noise by Preventing Interchromosomal Interactions

In this paper, the authors examine intrinsic and extrinsic noise in the yeast pheromone response MAP kinase pathway. The transcription factor Ste12 is regulated by this kinase pathway, and there are two partially redundant repressors, Dig1 and Dig2, that interact...

Stochastic gene expression in a single cell

Stochastic gene expression in a single cell

Seminal paper that measures the intrinsic and extrinsic noise in different strains of E.coli. This was the first paper to experimentally demonstrate the presence of molecular noise in gene expression.

Method of Gene Regulation Influences Intrinsic Noise Independently of Expression Levels

Method of Gene Regulation Influences Intrinsic Noise Independently of Expression Levels

Cell-to-cell variability in gene expression (a.k.a. gene expression noise) in a genetically identical population of cells is the result of a combination of extrinsic and intrinsic “noise”. Extrinsic noise is the result of variations in the cellular environment (e.g. cells...

Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

Great paper describing the cell cycle dependence of the degradation of SWI5 and CLB2 mRNA. They use single molecule FISH on unsynchronized populations to quantify mRNA abundance, as well as nascent transcripts.

1 2